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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TSC2
All Species:
13.03
Human Site:
T1271
Identified Species:
28.67
UniProt:
P49815
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49815
NP_000539.2
1807
200608
T1271
P
P
L
P
R
S
N
T
V
A
S
F
S
S
L
Chimpanzee
Pan troglodytes
XP_523477
1803
200189
F1271
P
S
L
A
V
A
S
F
S
S
L
Y
Q
S
S
Rhesus Macaque
Macaca mulatta
XP_001083256
1807
200600
T1271
P
P
L
P
R
S
N
T
V
A
S
F
S
S
L
Dog
Lupus familis
XP_852047
1813
201226
T1271
P
P
P
P
R
S
N
T
V
A
S
F
S
S
L
Cat
Felis silvestris
Mouse
Mus musculus
Q61037
1814
202053
V1271
T
L
P
R
S
N
T
V
A
S
F
S
S
L
Y
Rat
Rattus norvegicus
P49816
1809
201259
T1271
P
T
L
P
R
S
N
T
V
A
S
F
S
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516748
947
107028
L447
G
W
I
Q
N
L
Q
L
L
M
E
R
F
F
R
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_695912
1128
123244
G628
S
V
V
M
E
E
S
G
R
S
M
A
S
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524177
1847
204101
M1342
R
V
N
S
S
P
E
M
S
S
S
W
R
Q
S
Honey Bee
Apis mellifera
XP_395739
1813
206229
L1274
S
R
D
S
L
E
S
L
E
D
G
E
D
D
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786931
1947
217345
F1371
S
D
M
D
S
L
S
F
P
R
T
E
M
G
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
97.9
91.2
N.A.
88.9
91
N.A.
44.1
N.A.
N.A.
35.8
N.A.
29.8
38.2
N.A.
31.1
Protein Similarity:
100
99
99
94.6
N.A.
92.2
93.9
N.A.
48.3
N.A.
N.A.
44.3
N.A.
49.7
58.6
N.A.
48.9
P-Site Identity:
100
20
100
93.3
N.A.
6.6
93.3
N.A.
0
N.A.
N.A.
6.6
N.A.
6.6
6.6
N.A.
6.6
P-Site Similarity:
100
46.6
100
93.3
N.A.
20
93.3
N.A.
13.3
N.A.
N.A.
26.6
N.A.
20
13.3
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
10
0
0
10
37
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
10
10
0
0
0
0
0
10
0
0
10
10
0
% D
% Glu:
0
0
0
0
10
19
10
0
10
0
10
19
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
19
0
0
10
37
10
10
0
% F
% Gly:
10
0
0
0
0
0
0
10
0
0
10
0
0
10
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
10
37
0
10
19
0
19
10
0
10
0
0
10
55
% L
% Met:
0
0
10
10
0
0
0
10
0
10
10
0
10
0
0
% M
% Asn:
0
0
10
0
10
10
37
0
0
0
0
0
0
0
0
% N
% Pro:
46
28
19
37
0
10
0
0
10
0
0
0
0
0
0
% P
% Gln:
0
0
0
10
0
0
10
0
0
0
0
0
10
10
0
% Q
% Arg:
10
10
0
10
37
0
0
0
10
10
0
10
10
0
10
% R
% Ser:
28
10
0
19
28
37
37
0
19
37
46
10
55
46
28
% S
% Thr:
10
10
0
0
0
0
10
37
0
0
10
0
0
0
0
% T
% Val:
0
19
10
0
10
0
0
10
37
0
0
0
0
10
0
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
10
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _